William Standish Knowles

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William Standish Knowles
BornJune 1 1917 (1917-06-01) (age 92)
Taunton, Massachusetts, United States
NationalityImage:Flag of the United States.svg American
FieldChemist
InstitutionsThomas and Hochwalt laboratories, Monsanto
Alma materColumbia University
Academic advisor  Robert Elderfield
Known forChiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA
Notable prizesNobel Prize in Chemistry (2001) (jointly with Ryoji Noyori and K. Barry Sharpless)

William S. Knowles (born June 1, 1917) is an American chemist. He was born in Taunton, Massachusetts.

He shared the Nobel Prize in Chemistry in 2001 with Ryoji Noyori and K. Barry Sharpless for the development of catalytic asymmetric synthesis, which is a technology relevant to the preparation of many pharmaceuticals. Knowles led a team of researchers that developed chiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA.[1][2] Knowles conducted this prize-winning research at Monsanto.

He currently resides in St. Louis, Missouri.

[edit] References

  1. ^ Vineyard, B. D.; Knowles, W. S.; Sabacky, M. J.; Bachman, G. L.; Weinkauff, D. J. "Asymmetric Hydrogenation. Rhodium Chiral Bisphosphine Catalyst" Journal of the American Chemical Society 1977, volume 99, issue 18, pages 5946-5952.
  2. ^ Knowles, W. S. “Asymmetric Hydrogenations (Nobel Lecture)” Angewandte Chemie International Edition 2002, Volume 41, pages 1998 - 2007. DOI: 10.1002/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8.

[edit] External links

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