Dopamine agonist

From Wikipedia, the free encyclopedia

A dopamine agonist is a compound that activates dopamine receptors, mimicking the effect of the neurotransmitter dopamine.

Contents 1 Uses 2 Examples 3 See also 4 References 5 External links

[edit] Uses

Some medical drugs act as dopamine agonists; they are typically used for treating Parkinson's disease and certain Pituitary tumors (prolactinomas), and may be useful for restless legs syndrome (RLS). Both Requip (Ropinirole) and Mirapex (Pramipexole) are FDA approved for the treatment of RLS.

There is also an ongoing clinical trial to test the effectiveness of Requip (Ropinirole), a dopamine agonist, in reversing the symptoms of SSRI induced sexual dysfunction. ^[1]

[edit] Examples

Examples of dopamine agonists include:

• Parlodel (bromocriptine)
• Dostinex (cabergoline)
• Permax (Pergolide) - Removed from market March 29,2007.^[2]

• Mirapex (Pramipexole)
• Requip (Ropinirole)
• Apokyn (apomorphine)
• Neupro (rotigotine)

[edit] See also

• Agonist

[edit] References

1. ^ ClinicalTrials.gov NCT00334048 - "Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo"
2. ^ http://www.fda.gov/bbs/topics/NEWS/2007/NEW01596.html

[edit] External links

• MeSH Dopamine+Agonistsde:Dopaminagonist

v • d • e Anti-parkinson drugs: dopaminergic agents (N04B)
Dopa and derivatives	Levodopa, Melevodopa, Etilevodopa
Adamantane derivatives	Amantadine
Dopamine agonists	Apomorphine, Bromocriptine, Cabergoline, Dihydrexidine, Dihydroergocryptine mesylate, Fenoldopam, Lisuride, Pergolide, Piribedil, Pramipexole, Quinpirole, Ropinirole, Rotigotine, SKF 38393, SKF 82958
MAOIs	Selegiline, Rasagiline
Other	Tolcapone, Entacapone, Budipine

v • d • e Receptor agonists and antagonists (and reuptake inhibitors)
Dopamine receptor	Dopamine agonist - Dopamine antagonist - Dopamine reuptake inhibitor
5-HT (serotonin) receptor	Serotonin receptor agonist - Serotonin antagonist (5-HT3 antagonist) - Serotonin uptake inhibitor (SSRI)
Adrenergic receptor	adrenergic agonist (Adrenergic alpha-agonist, Beta2-adrenergic receptor agonist) - adrenergic antagonist (Alpha blocker, Beta blocker) - Adrenergic uptake inhibitor
Acetylcholine receptor	cholinergic (Muscarinic agonist, Nicotinic agonist) - anticholinergic (Muscarinic antagonist, Nicotinic antagonist) - Acetylcholinesterase inhibitor
Histamine receptor	Histamine agonist - Histamine antagonist (H1, H2)
GABA receptor	GABA agonist - GABA antagonist
NMDA receptor	NMDA antagonist